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Total : 10개 (page : 1/1)

Suggestion of BRCA1 c.5339T>C (p.L1780P) variant confer from 'unknown significance' to 'Likely pathogenic' based on clinical evidence in Korea
유방 질환 학회 Suggestion of BRCA1 c.5339T>C (p.L1780P) variant confer from 'unknown significance' to 'Likely pathogenic' based on clinical evidence in Korea 2017.06.15
Breast . 2017 Jun;33:109-116 논문 보기

We describe a rationale for the re-classification of the BRCA1 c.5539T>C (L1780P) variant using a clinical evidence.

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
네이처 제네틱스 Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer 2017.05.27
Nat Genet . 2017 May;49(5):680-691 논문 보기

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

Failure patterns according to molecular subtype in patients with invasive breast cancer following postoperative adjuvant radiotherapy: long-term outcomes in contemporary clinical practice
유방암 연구 저널 Failure patterns according to molecular subtype in patients with invasive breast cancer following postoperative adjuvant radiotherapy: long-term outcomes in contemporary clinical practice 2017.03.17
Breast Cancer Res Treat . 2017 Jun;163(3):555-563 논문 보기

Although gene expression profiling provides critical information, knowledge remains limited regarding the differential effects of molecular subtype on clinical course. This study evaluated the impact of molecular status on long-term patterns of failure in patients with non-metastatic breast cancer.

Association between basal-like phenotype and BRCA1/2 germline mutations in Korean breast cancer patients
Current Oncology 의학 저널 Association between basal-like phenotype and BRCA1/2 germline mutations in Korean breast cancer patients 2016.10.23
Curr Oncol. 2016 Oct; 23(5): 298–303 논문 보기

BRCA mutation testing allows index patients and their families to be provided with appropriate cancer risk-reduction strategies. Because of the low prevalence of BRCA mutations in unselected breast cancer patients and the high cost of genetic testing, it is important to identify the subset of women who are likely to carry BRCA mutations. In the present study, we examined the association between BRCA1/2 germline mutations and the immunohistochemical features of breast cancer.

Use of a prospective surveillance model to prevent breast cancer treatment-related lymphedema: a single-center experience
유방암 연구 저널 Use of a prospective surveillance model to prevent breast cancer treatment-related lymphedema: a single-center experience 2016.09.24
Breast Cancer Res Treat . 2016 Nov;160(2):269-276 논문 보기

The purpose of our study was thus to evaluate the efficacy of a surveillance program including ECW ratio measurement in terms of detection of subclinical LE; we explored whether such detection might prevent the development of advanced LE after surgery.

Reliability of Computer-Assisted Breast Density Estimation: Comparison of Interactive Thresholding, Semiautomated, and Fully Automated Methods
미국 영상의학회지 Reliability of Computer-Assisted Breast Density Estimation: Comparison of Interactive Thresholding, Semiautomated, and Fully Automated Methods 2016.07.10
American Journal of Roentgenology. 2016;207: 126-134. 10.2214 논문 보기

The purpose of this study was to investigate the reliability of computer-assisted methods of estimating breast density.

An international survey of surveillance schemes for unaffected BRCA1 and BRCA2 mutation carriers
유방암 연구 저널 An international survey of surveillance schemes for unaffected BRCA1 and BRCA2 mutation carriers 2016.04.27
Breast Cancer Research and Treatment 157, pages319–327 (2016) 논문 보기

The aim of the current study was to define the various surveillance regimens and local practices offered in different high-risk clinics in Asia, Australia, Europe, and North America, and specifically focusing on post RRM and RRSO practices

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
유방암 연구 저널 Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 2016.02.09
Breast Cancer Research (09 February 2016) 논문 보기

BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs).

Reproducibility of Apparent Diffusion Coefficient Measurements in Malignant Breast Masses
대한의학회 학회지 Reproducibility of Apparent Diffusion Coefficient Measurements in Malignant Breast Masses 2015.11.16
J Korean Med Sci. 2015 Nov;30(11):1689-1697. 논문 보기

This study aimed to evaluate the reproducibility of apparent diffusion coefficient (ADC) measurements in malignant breast masses, and to determine the influence of mammographic parenchymal density on this reproducibility. Sixty-six patients with magnetic resonance findings of the mass were included. Two breast radiologists measured the ADC of the malignant breast mass and the same area on the contralateral normal breast in each patient twice. The effects of mammographic parenchymal density, histology, and lesion size on reproducibility were also assessed. There was no significant difference in the mean ADC between repeated measurements in malignant breast masses and normal breast tissue. The overall reproducibility of ADC measurements was good in both. The 95% limits of agreement for repeated ADCs were approximately 30.2%-33.4% of the mean. ADC measurements in malignant breast masses were highly reproducible irrespective of mass size, histologic subtype, or coexistence of microcalcifications; however, the measurements tended to be less reproducible in malignant breast masses with extremely dense parenchymal backgrounds. ADC measurements in malignant breast masses are highly reproducible; however, mammographic parenchymal density can potentially influence this reproducibility.

Discrepant Trajectories of Impairment, Activity, and Participation Related to Upper-Limb Function in Patients With Breast Cancer
미국 재활 의학 학회지 Discrepant Trajectories of Impairment, Activity, and Participation Related to Upper-Limb Function in Patients With Breast Cancer 2015.09.03
Archives of Physical Medicine and Rehabilitation (VOLUME 96, ISSUE 12, P2161-2168, DECEMBER 01, 2015) 논문 보기

To explore upper-limb disability with respect to health outcomes, operationalized by Disabilities of the Arm, Shoulder, and Hand, and to identify factors associated with each element of upper-limb disability over a 2-year period in breast cancer survivors.